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Why “home-made” IHC controls are a bad idea — and how standardized materials save diagnostics. In immunohistochemistry, every error can have real clinical consequences. No surprise there: IHC determines treatment, eligibility for targeted therapies, tumor diagnostics, and even risk assessment. And yet, in many laboratories, in-house controls still reign — cut from patient blocks, assembled into tissue arrays, or “put together” from whatever happens to be available. Nobody pay

PRAME (QR005) (PReferentially expressed Antigen in MElanoma) by Quartett GmbH is a tumor associated antigen that is preferentially...

Giemsa staining for the determination of Helicobacter pylori is one of the most important staining in gastroenterology diagnostics. It...

Silver is the most commonly used metal to impregnate tissue structures, but it is by no means the only one. Although relatively rare, we...

Although the history of the microtome begins in the 1770s, it is believed that the first microtome was created by Mr. Wilhelm His Sr in...

(Oil Red O is called Sudan Red as well) Most of the stainings performed in pathology departments concern paraffin blocks previously fixed...

Today is International Women Day. I wanted to write something about some cool technique for staining of heartbreaking damage after the...

Today, Fat Thursday, a day associated in ancient times with the end of winter and the advent of spring in Central Europe. Eating big...

One of the most important elements of preparing tissue material for collecting is repeatability. In an ideal world, each preparation...

1. Phonetic notation of "formalin". 2. Lean as someon skinny. Humoristic and without connection with the article. ------------- 1. Gra...

Like every invention, the microscope also has its ancestors. After all, it never happens that a thought comes and we have a modern...

Eosin is known primarily as hematoxylin counterstaining in, perhaps the most popular, histopathological staining. It is also no secret...

Welcome to the new year! We seem to begin the fresh start, and somehow everything in the old way. Today I also decided to shed new light...

Today is the last day of the year. For many, it will be associated with fun and fireworks. That is why we also will make some...

Unfortunately… There is no such a thing like christmas staining and so on. At least not in pathology as sperm staining is otherwise known...

A few weeks ago I wrote about the properties that adhesives for slides must have. Those who would like to recall that topic, please visit...

When we perform staining and adhere to procedures or their proven modifications, most often there are no problems with evaluation....

During intraoperative examinations, we often deal with different tissues during one day. On the other hand, work with a cryostat is often...

Part 3. Three colours. It's time for something for those who like to play little chemist. In order to perform a quick cytological...

In the second part, I would like to focus on the benefits of ROSE. I have already mentioned recently that it is certainly a great relief...