Anti-SOX10 (clone QR006)
SOX10 – Key Transcription Factor and Tumor Marker
Function and Biological Significance of SOX10
✔ SOX10 is a nuclear transcription factor that acts as a transport protein between the cytoplasm and the nucleus.
✔ It is crucial for the development of the neural crest and peripheral nervous system, as well as for:
- Differentiation, maturation, and maintenance of Schwann cells
- Function of melanocytes
SOX10 Expression in Normal Tissues
✔ SOX10 is expressed in:
- Schwann cells and glial cells of the nervous system
- Melanocyte nuclei
- Epithelial cells of the salivary glands and mammary glands
SOX10 as a Tumor Marker
✔ SOX10 is a sensitive and specific marker for melanomas.
✔ Desmoplastic melanomas may only show focal positivity.
✔ SOX10 is also positive in melanocytic nevi.
✔ It shows high specificity for soft tissue tumors derived from the neural crest.
Summary
✔ SOX10 is a key transcription factor regulating the development of Schwann cells and melanocytes.
✔ It is expressed in melanocytes, neural cells, and glandular epithelial cells.
✔ In tumor diagnostics, SOX10 is a crucial marker for melanomas (including desmoplastic subtypes) and neural crest-derived neoplasms.
Literature
[1] Kuhlbrodt K et al. (1998). J Neurosci. 18(1):237-50.
[2] Clevenger J et al. (2014). J Cancer Cytopathol. 122(10):779-85.
[3] Graf SA et al. (2014). J Invest Dermatol. 134(8):2212-20.
[4] Miettinen M et al. (2014). Am J Surg Pathol. 39(6):826-35.
[5] Cimino-Mathews A et al. (2013). Hum Pathol. 44(6):959-65.
Advantage of QUARTETT Antibodies
ADVANTAGES OF RECOMBINANT RABBIT MONOCLONAL ANTIBODIES
Recombinant rabbit monoclonal antibodies—referred to as Q-clones—combine the best properties of both murine monoclonal and rabbit polyclonal antibodies, offering a broader diagnostic potential.
Key Advantages of Our Next-Generation Recombinant Rabbit Monoclonal Antibodies
✔ High Affinity due to rabbit origin, enabling greater sensitivity in assays—these antibodies bind strongly to antigens and maintain their bond even under challenging conditions, unlike low-affinity antibodies.
✔ Superior Specificity with reduced risk of cross-reactivity, thanks to their monoclonal nature.
✔ Expanded Antigen Recognition—better recognition of diverse antigens and epitopes.
✔ Target Epitopes Poorly Recognized by Mouse-Derived Antibodies, improving detection in certain applications.
✔ Enhanced Response to Small-Sized Epitopes, making them ideal for challenging targets.
✔ Significantly Improved Recognition of Murine Antigens, broadening their usability in research and diagnostics.
✔ Lower Background Staining, ensuring cleaner and more reliable results.
Recombinant vs. Hybridoma Antibody Generation
✔ Exceptional Consistency, Specificity, and Sensitivity—eliminating risks of gene loss, mutations, or cell line drift.
✔ Reliable and Controlled Production—generated from a unique gene set, ensuring stable antibody performance.
✔ Batch-to-Batch Consistency, guaranteeing reproducible results and long-term product availability.
✔ Efficient In Vitro High-Throughput Production, allowing easy standardization and scalable antibody expression for any application.
Recombinant rabbit monoclonal antibodies represent the future of immunohistochemistry, offering unmatched reliability and precision in diagnostic and research settings.