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Anti-SOX10 (clone QR006)

Anti-SOX10 (clone QR006)

SOX10 – Key Transcription Factor and Tumor Marker
Function and Biological Significance of SOX10
✔ SOX10 is a nuclear transcription factor that acts as a transport protein between the cytoplasm and the nucleus.
✔ It is crucial for the development of the neural crest and peripheral nervous system, as well as for:
      
  • Differentiation, maturation, and maintenance of Schwann cells
    •   
  • Function of melanocytes
SOX10 Expression in Normal Tissues
✔ SOX10 is expressed in:
      
  • Schwann cells and glial cells of the nervous system
    •   
  • Melanocyte nuclei
    •   
  • Epithelial cells of the salivary glands and mammary glands
SOX10 as a Tumor Marker
✔ SOX10 is a sensitive and specific marker for melanomas.
✔ Desmoplastic melanomas may only show focal positivity.
✔ SOX10 is also positive in melanocytic nevi.
✔ It shows high specificity for soft tissue tumors derived from the neural crest.
Summary
✔ SOX10 is a key transcription factor regulating the development of Schwann cells and melanocytes.
✔ It is expressed in melanocytes, neural cells, and glandular epithelial cells.
✔ In tumor diagnostics, SOX10 is a crucial marker for melanomas (including desmoplastic subtypes) and neural crest-derived neoplasms.

    • [1] Kuhlbrodt K et al. (1998). J Neurosci. 18(1):237-50.

      [2] Clevenger J et al. (2014). J Cancer Cytopathol. 122(10):779-85.

      [3] Graf SA et al. (2014). J Invest Dermatol. 134(8):2212-20.

      [4] Miettinen M et al. (2014). Am J Surg Pathol. 39(6):826-35.

      [5] Cimino-Mathews A et al. (2013). Hum Pathol. 44(6):959-65.

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