top of page
Anti-SALL4 (clone QR024)

Anti-SALL4 (clone QR024)

SALL4 – A Key Transcription Factor and Cancer Marker
The SALL Protein Family and SALL4 Function
✔ The human body expresses four SALL proteins: SALL1, SALL2, SALL3, and SALL4, which share structural homology and play diverse roles in:
      
  • Embryonic development
    •   
  • Kidney function
    •   
  • Oncogenesis
✔ SALL4 (Sal-like protein 4) is a zinc-finger transcription factor that:
      
  • Maintains pluripotency in stem cells
    •   
  • Interacts with other pluripotency factors, such as OCT4 and NANOG
SALL4 as a Marker for Germ Cell Tumors
✔ Due to its expression in germ cells, SALL4 serves as a valuable marker in the diagnosis of germ cell tumors, including:
      
  • Seminoma
    •   
  • Embryonal carcinoma
    •   
  • Yolk sac tumor
    •   
  • Teratoma
SALL4 and Prognosis in Cancer
✔ SALL4 expression is often associated with poor survival and prognosis, for example, in:
      
  • Hepatocellular carcinoma (HCC)
✔ In other malignancies, SALL4 overexpression is linked to metastasis, such as in:
      
  • Endometrial carcinoma
    •   
  • Colorectal carcinoma (CRC)
    •   
  • Esophageal squamous cell carcinoma
SALL4 Expression in Adult Cancers
✔ In most adult tissues, SALL4 levels are low or undetectable (except in germ cells and hematopoietic progenitor cells).
✔ However, reactivation and dysregulated expression of SALL4 occur in various malignancies, including:
      
  • Acute myeloid leukemia (AML)
    •   
  • B-cell acute lymphoblastic leukemia (B-ALL)
    •   
  • Gastric cancer
    •   
  • Breast cancer
    •   
  • Hepatocellular carcinoma (HCC)
    •   
  • Lung cancer
    •   
  • Gliomas
Summary
✔ SALL4 is a key transcription factor involved in pluripotency and oncogenesis.
✔ It serves as a useful marker for germ cell tumors, including seminoma, embryonal carcinoma, yolk sac tumor, and teratoma.
✔ High SALL4 expression correlates with poor prognosis and metastasis in several malignancies, such as HCC, endometrial carcinoma, and colorectal carcinoma.
✔ While its expression is low in adult tissues, SALL4 reactivation is observed in various cancers, including AML, B-ALL, gastric, breast, lung cancers, and gliomas.

    • [1] Miettinen M, et al. (2014). Am J Surg Pathol. 38:410-20.

      [2] Yang J, et al. (2008). PNAS. 105:19756-61.

    • ADVANTAGES OF RECOMBINANT RABBIT MONOCLONAL ANTIBODIES

      Recombinant rabbit monoclonal antibodies—referred to as Q-clones—combine the best properties of both murine monoclonal and rabbit polyclonal antibodies, offering a broader diagnostic potential.

      Key Advantages of Our Next-Generation Recombinant Rabbit Monoclonal Antibodies

      ✔ High Affinity due to rabbit origin, enabling greater sensitivity in assays—these antibodies bind strongly to antigens and maintain their bond even under challenging conditions, unlike low-affinity antibodies.

      ✔ Superior Specificity with reduced risk of cross-reactivity, thanks to their monoclonal nature.

      ✔ Expanded Antigen Recognition—better recognition of diverse antigens and epitopes.

      ✔ Target Epitopes Poorly Recognized by Mouse-Derived Antibodies, improving detection in certain applications.

      ✔ Enhanced Response to Small-Sized Epitopes, making them ideal for challenging targets.

      ✔ Significantly Improved Recognition of Murine Antigens, broadening their usability in research and diagnostics.

      ✔ Lower Background Staining, ensuring cleaner and more reliable results.

      Recombinant vs. Hybridoma Antibody Generation

      ✔ Exceptional Consistency, Specificity, and Sensitivity—eliminating risks of gene loss, mutations, or cell line drift.

      ✔ Reliable and Controlled Production—generated from a unique gene set, ensuring stable antibody performance.

      ✔ Batch-to-Batch Consistency, guaranteeing reproducible results and long-term product availability.

      ✔ Efficient In Vitro High-Throughput Production, allowing easy standardization and scalable antibody expression for any application.

      Recombinant rabbit monoclonal antibodies represent the future of immunohistochemistry, offering unmatched reliability and precision in diagnostic and research settings.

    bottom of page