Anti-PAX8 (clone QR016)

PAX8 (Clone QR016) – Optimal Marker for Tumors of Mesodermal and Endodermal Origin
NordicQC Run 64, 2022 Evaluation: ✅ Optimal staining for clone QR016!
PAX8 – Characteristics and Function
PAX8 belongs to the PAX family of transcription factors, which regulate organ development during embryogenesis.
✔ Structurally related to PAX5 and PAX2.
✔ Its expression is highly regulated during fetal development and is essential for organogenesis in:
  
Kidneys
  
Müllerian-derived organs (fallopian tubes, uterus, cervix)
  
Thyroid
PAX8 Expression in Tumors
🔹 Transcription factors often diminish in mature tissues but can be re-expressed organ-specifically during malignant transformation.
🔹 Due to its restricted expression in normal tissues, PAX8 is a sensitive and specific marker for primary and metastatic tumors originating from:
  
Thyroid – papillary carcinoma, follicular carcinoma
  
Thymus
  
Ovaries – serous and endometrioid carcinoma
  
Endometrium – endometrial carcinoma
  
Cervix (endocervical origin)
  
Fallopian tubes
  
Kidneys – renal cell carcinoma, papillary renal carcinoma
🔹 PAX8 is a nuclear marker, providing high sensitivity and specificity in histopathological diagnostics.
Summary
✔ PAX8 is a key marker for tumors originating from the thyroid, genitourinary system, and kidneys.
✔ Particularly useful in diagnosing both primary and metastatic tumors.
✔ Nuclear expression of PAX8 allows for easy detection in immunohistochemical (IHC) analysis.