top of page
Anti-PAX8 (clone QR016)

Anti-PAX8 (clone QR016)

PAX8 (Clone QR016) – Optimal Marker for Tumors of Mesodermal and Endodermal Origin
NordicQC Run 64, 2022 Evaluation: ✅ Optimal staining for clone QR016!
PAX8 – Characteristics and Function
PAX8 belongs to the PAX family of transcription factors, which regulate organ development during embryogenesis.
✔ Structurally related to PAX5 and PAX2.
✔ Its expression is highly regulated during fetal development and is essential for organogenesis in:
      
  • Kidneys
    •   
  • Müllerian-derived organs (fallopian tubes, uterus, cervix)
    •   
  • Thyroid
PAX8 Expression in Tumors
🔹 Transcription factors often diminish in mature tissues but can be re-expressed organ-specifically during malignant transformation.
🔹 Due to its restricted expression in normal tissues, PAX8 is a sensitive and specific marker for primary and metastatic tumors originating from:
      
  • Thyroid – papillary carcinoma, follicular carcinoma
    •   
  • Thymus
    •   
  • Ovaries – serous and endometrioid carcinoma
    •   
  • Endometrium – endometrial carcinoma
    •   
  • Cervix (endocervical origin)
    •   
  • Fallopian tubes
    •   
  • Kidneys – renal cell carcinoma, papillary renal carcinoma
    🔹 PAX8 is a nuclear marker, providing high sensitivity and specificity in histopathological diagnostics.
Summary
✔ PAX8 is a key marker for tumors originating from the thyroid, genitourinary system, and kidneys.
✔ Particularly useful in diagnosing both primary and metastatic tumors.
✔ Nuclear expression of PAX8 allows for easy detection in immunohistochemical (IHC) analysis.

    • [1] Chai H-J et al. (2017). Oncol Lett. 14(5): 5871-5.

      [2] Ozcan A et al. (2011). Mod Pathol. 24(6):751-64.

      [3] Bellevicine C et al. (2013). Eur J Endocrinol. 169(3):307-11.

      [4] Tong GX et al. (2009). Mod Pathol. 22(9):1218-27.

      [5] Plachov D et al. (1990). Development. 110(2):643-51.

      [6] Poleev A et al. (1992). Development. 116(3):611-23.

      [7] Wang Y et al. (2013). J Hematol Oncol. 6:60.

    • ADVANTAGES OF RECOMBINANT RABBIT MONOCLONAL ANTIBODIES

      Recombinant rabbit monoclonal antibodies—referred to as Q-clones—combine the best properties of both murine monoclonal and rabbit polyclonal antibodies, offering a broader diagnostic potential.

      Key Advantages of Our Next-Generation Recombinant Rabbit Monoclonal Antibodies

      ✔ High Affinity due to rabbit origin, enabling greater sensitivity in assays—these antibodies bind strongly to antigens and maintain their bond even under challenging conditions, unlike low-affinity antibodies.

      ✔ Superior Specificity with reduced risk of cross-reactivity, thanks to their monoclonal nature.

      ✔ Expanded Antigen Recognition—better recognition of diverse antigens and epitopes.

      ✔ Target Epitopes Poorly Recognized by Mouse-Derived Antibodies, improving detection in certain applications.

      ✔ Enhanced Response to Small-Sized Epitopes, making them ideal for challenging targets.

      ✔ Significantly Improved Recognition of Murine Antigens, broadening their usability in research and diagnostics.

      ✔ Lower Background Staining, ensuring cleaner and more reliable results.

      Recombinant vs. Hybridoma Antibody Generation

      ✔ Exceptional Consistency, Specificity, and Sensitivity—eliminating risks of gene loss, mutations, or cell line drift.

      ✔ Reliable and Controlled Production—generated from a unique gene set, ensuring stable antibody performance.

      ✔ Batch-to-Batch Consistency, guaranteeing reproducible results and long-term product availability.

      ✔ Efficient In Vitro High-Throughput Production, allowing easy standardization and scalable antibody expression for any application.

      Recombinant rabbit monoclonal antibodies represent the future of immunohistochemistry, offering unmatched reliability and precision in diagnostic and research settings.

    bottom of page