Anti-CD171/ L1CAM (clone QR039)
CD171 (L1CAM) – Key Diagnostic Marker in Oncology
CD171, also known as L1CAM (L1 cell adhesion molecule), is a membrane protein belonging to the immunoglobulin superfamily. It functions as an adhesion molecule, playing a crucial role in the development of the nervous system, including:
✔ Neuronal migration and differentiation
✔ Neuronal adhesion
✔ Neurite fasciculation
✔ Axonal growth and elongationCD171 Expression in Tissues
CD171 is predominantly expressed in neuroectodermal-derived tissues. In normal epithelium, its expression is very low or undetectable but significantly increases following malignant transformation.
CD171 as a Cancer Marker
Overexpression of CD171 has been reported in various malignancies, including:
✔ Ovarian cancer
✔ Endometrial cancer (highest diagnostic value)
✔ Colorectal cancer
✔ Pancreatic cancer
✔ Renal cancer
✔ Cholangiocarcinoma
✔ Gastric cancer
✔ MelanomaCD171 and Prognosis
In all studied cases, CD171 overexpression correlated with poor prognosis, suggesting that CD171 may directly or indirectly contribute to tumor progression.
Due to its expression pattern and association with aggressive disease, CD171 is particularly valuable in the diagnosis of endometrial cancer and other epithelial malignancies.
Literature
[1] Pfeifer M et al. (2010). BMC Mol Biol. 11:64.
[2] Altevogt P et al. (2016). Int J Cancer. 138(7):1565-76.
Advantage of QUARTETT Antibodies
ADVANTAGES OF RECOMBINANT RABBIT MONOCLONAL ANTIBODIES
Recombinant rabbit monoclonal antibodies—referred to as Q-clones—combine the best properties of both murine monoclonal and rabbit polyclonal antibodies, offering a broader diagnostic potential.
Key Advantages of Our Next-Generation Recombinant Rabbit Monoclonal Antibodies
✔ High Affinity due to rabbit origin, enabling greater sensitivity in assays—these antibodies bind strongly to antigens and maintain their bond even under challenging conditions, unlike low-affinity antibodies.
✔ Superior Specificity with reduced risk of cross-reactivity, thanks to their monoclonal nature.
✔ Expanded Antigen Recognition—better recognition of diverse antigens and epitopes.
✔ Target Epitopes Poorly Recognized by Mouse-Derived Antibodies, improving detection in certain applications.
✔ Enhanced Response to Small-Sized Epitopes, making them ideal for challenging targets.
✔ Significantly Improved Recognition of Murine Antigens, broadening their usability in research and diagnostics.
✔ Lower Background Staining, ensuring cleaner and more reliable results.
Recombinant vs. Hybridoma Antibody Generation
✔ Exceptional Consistency, Specificity, and Sensitivity—eliminating risks of gene loss, mutations, or cell line drift.
✔ Reliable and Controlled Production—generated from a unique gene set, ensuring stable antibody performance.
✔ Batch-to-Batch Consistency, guaranteeing reproducible results and long-term product availability.
✔ Efficient In Vitro High-Throughput Production, allowing easy standardization and scalable antibody expression for any application.
Recombinant rabbit monoclonal antibodies represent the future of immunohistochemistry, offering unmatched reliability and precision in diagnostic and research settings.