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Anti-CD171/ L1CAM (clone QR039)

Anti-CD171/ L1CAM (clone QR039)

CD171 (L1CAM) – Key Diagnostic Marker in Oncology
CD171, also known as L1CAM (L1 cell adhesion molecule), is a membrane protein belonging to the immunoglobulin superfamily. It functions as an adhesion molecule, playing a crucial role in the development of the nervous system, including:
✔ Neuronal migration and differentiation
✔ Neuronal adhesion
✔ Neurite fasciculation
✔ Axonal growth and elongation
CD171 Expression in Tissues
CD171 is predominantly expressed in neuroectodermal-derived tissues. In normal epithelium, its expression is very low or undetectable but significantly increases following malignant transformation.
CD171 as a Cancer Marker
Overexpression of CD171 has been reported in various malignancies, including:
✔ Ovarian cancer
✔ Endometrial cancer (highest diagnostic value)
✔ Colorectal cancer
✔ Pancreatic cancer
✔ Renal cancer
✔ Cholangiocarcinoma
✔ Gastric cancer
✔ Melanoma
CD171 and Prognosis
In all studied cases, CD171 overexpression correlated with poor prognosis, suggesting that CD171 may directly or indirectly contribute to tumor progression.
Due to its expression pattern and association with aggressive disease, CD171 is particularly valuable in the diagnosis of endometrial cancer and other epithelial malignancies.

    • [1] Pfeifer M et al. (2010). BMC Mol Biol. 11:64.

      [2] Altevogt P et al. (2016). Int J Cancer. 138(7):1565-76.

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