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Anti-CD10 (clone QR021)

Anti-CD10 (clone QR021)

CD10 (Clone QR021) – Optimal Staining in NordiQC Run 66, 2022
CD10, also known as CALLA (common acute lymphoblastic leukemia antigen), neprilysin, and neutral endopeptidase, is a zinc-dependent metalloprotease that degrades various small secretory peptides. It plays a functional role in:
✔ Regulating cellular responses to peptide substrates
✔ Proteolytic processes in the kidneys
✔ Cardiovascular system regulation
✔ Immune response modulation
✔ Cell proliferation
✔ Fetal development
CD10 was first identified as a tumor-specific antigen in acute lymphoblastic leukemia (ALL) and is a surface ectoenzyme widely expressed in various cell types.
CD10 Expression in Normal Cells
CD10 is present on the surface of:
✔ Hematopoietic stem cells and myelopoietic cells (including neutrophils)
✔ Follicular center B cells
✔ A subset of mature B lymphocytes
✔ A parafollicular subset of T lymphocytes
Additionally, CD10 is expressed in non-lymphoid cells, such as:
✔ Glomerular epithelial cells and proximal tubule brush border (kidney)
✔ Biliary ductal cells (liver)
✔ Alveolar epithelial cells (lungs)
✔ Myoepithelial cells of the breast, sweat glands, and salivary glands
✔ Glandular epithelial cells of the prostate
✔ Trophoblast cells (placenta)
✔ Endometrial stromal cells
✔ Some endothelial cells
CD10 Expression in Tumors
CD10 is highly expressed in:
✔ B-cell acute lymphoblastic leukemia (B-ALL)
✔ Follicular lymphoma (FL)
✔ Burkitt lymphoma (BL)
Diagnostic Applications of CD10
CD10 is a useful marker for classifying:
✔ B-cell leukemias and lymphomas
✔ Hepatocellular and renal cell carcinomas
✔ Metaplastic breast carcinoma (useful for prognosis in breast cancer)
✔ Mesenchymal tumors of the uterus, such as endometrial stromal sarcoma
CD10 is an important diagnostic and prognostic marker, widely used in hematopathology and solid tumor oncology.

    • [1] Mishra D et al. (2016). Mol Biol Int. 2016:4328697.

      [2] Nalivaeva NN et al. (2020). Mech Ageing Dev. 192:111363.

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