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Anti-CD10 (clone QR021)

Anti-CD10 (clone QR021)

CD10 (Clone QR021) – Optimal Staining in NordiQC Run 66, 2022
CD10, also known as CALLA (common acute lymphoblastic leukemia antigen), neprilysin, and neutral endopeptidase, is a zinc-dependent metalloprotease that degrades various small secretory peptides. It plays a functional role in:
✔ Regulating cellular responses to peptide substrates
✔ Proteolytic processes in the kidneys
✔ Cardiovascular system regulation
✔ Immune response modulation
✔ Cell proliferation
✔ Fetal development
CD10 was first identified as a tumor-specific antigen in acute lymphoblastic leukemia (ALL) and is a surface ectoenzyme widely expressed in various cell types.
CD10 Expression in Normal Cells
CD10 is present on the surface of:
✔ Hematopoietic stem cells and myelopoietic cells (including neutrophils)
✔ Follicular center B cells
✔ A subset of mature B lymphocytes
✔ A parafollicular subset of T lymphocytes
Additionally, CD10 is expressed in non-lymphoid cells, such as:
✔ Glomerular epithelial cells and proximal tubule brush border (kidney)
✔ Biliary ductal cells (liver)
✔ Alveolar epithelial cells (lungs)
✔ Myoepithelial cells of the breast, sweat glands, and salivary glands
✔ Glandular epithelial cells of the prostate
✔ Trophoblast cells (placenta)
✔ Endometrial stromal cells
✔ Some endothelial cells
CD10 Expression in Tumors
CD10 is highly expressed in:
✔ B-cell acute lymphoblastic leukemia (B-ALL)
✔ Follicular lymphoma (FL)
✔ Burkitt lymphoma (BL)
Diagnostic Applications of CD10
CD10 is a useful marker for classifying:
✔ B-cell leukemias and lymphomas
✔ Hepatocellular and renal cell carcinomas
✔ Metaplastic breast carcinoma (useful for prognosis in breast cancer)
✔ Mesenchymal tumors of the uterus, such as endometrial stromal sarcoma
CD10 is an important diagnostic and prognostic marker, widely used in hematopathology and solid tumor oncology.

  • Literature

    [1] Mishra D et al. (2016). Mol Biol Int. 2016:4328697.

    [2] Nalivaeva NN et al. (2020). Mech Ageing Dev. 192:111363.

  • Advantage of QUARTETT Antibodies

    ADVANTAGES OF RECOMBINANT RABBIT MONOCLONAL ANTIBODIES

    Recombinant rabbit monoclonal antibodies—referred to as Q-clones—combine the best properties of both murine monoclonal and rabbit polyclonal antibodies, offering a broader diagnostic potential.

    Key Advantages of Our Next-Generation Recombinant Rabbit Monoclonal Antibodies

    ✔ High Affinity due to rabbit origin, enabling greater sensitivity in assays—these antibodies bind strongly to antigens and maintain their bond even under challenging conditions, unlike low-affinity antibodies.

    ✔ Superior Specificity with reduced risk of cross-reactivity, thanks to their monoclonal nature.

    ✔ Expanded Antigen Recognition—better recognition of diverse antigens and epitopes.

    ✔ Target Epitopes Poorly Recognized by Mouse-Derived Antibodies, improving detection in certain applications.

    ✔ Enhanced Response to Small-Sized Epitopes, making them ideal for challenging targets.

    ✔ Significantly Improved Recognition of Murine Antigens, broadening their usability in research and diagnostics.

    ✔ Lower Background Staining, ensuring cleaner and more reliable results.

    Recombinant vs. Hybridoma Antibody Generation

    ✔ Exceptional Consistency, Specificity, and Sensitivity—eliminating risks of gene loss, mutations, or cell line drift.

    ✔ Reliable and Controlled Production—generated from a unique gene set, ensuring stable antibody performance.

    ✔ Batch-to-Batch Consistency, guaranteeing reproducible results and long-term product availability.

    ✔ Efficient In Vitro High-Throughput Production, allowing easy standardization and scalable antibody expression for any application.

    Recombinant rabbit monoclonal antibodies represent the future of immunohistochemistry, offering unmatched reliability and precision in diagnostic and research settings.

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