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Anti- Cadherin 17 (clone QR098)

Anti- Cadherin 17 (clone QR098)

Anti-Cadherin 17 (CDH17) – A Highly Sensitive Marker in Gastrointestinal Pathology
Cadherin 17 (CDH17), also known as liver-intestine cadherin or human peptide transporter-1 (HPT-1), belongs to the cadherin family. It is a calcium-dependent (Ca²⁺) adhesion molecule primarily expressed in intestinal epithelial cells. CDH17 plays a role in the morphological organization of the liver and intestines and is involved in peptide transport within the intestine.
CDH17 Expression in Tumors
Immunohistochemical staining for CDH17 is highly sensitive for detecting adenocarcinomas originating from:
✔ Colon
✔ Rectum
✔ Stomach
✔ Esophagus
Additionally, CDH17 expression, though less frequent, has been reported in:
✔ Pancreatic adenocarcinoma
✔ Mucinous ovarian carcinoma
✔ Neoplasms of the female reproductive tract
CDH17 as an Oncogene and Diagnostic Marker
Recent studies indicate that CDH17 expression is upregulated in gastric cancer, suggesting its role as an oncogene. It is implicated in:
✔ Cell proliferation
✔ Tumor growth
✔ Invasion and metastasis of gastric carcinoma
CDH17 demonstrates higher sensitivity for colorectal carcinoma compared to CK20 and CDX2, making it a valuable diagnostic tool.
Clinical Significance
✔ High CDH17 expression correlates with poor prognosis, increased cell proliferation, and enhanced metastatic potential in various malignancies.
✔ Its superior sensitivity in colorectal cancer supports its use as a key immunohistochemical marker in diagnostic pathology.

  • Literature

    Literature:

    [1] Altree-Tacha D et al. (2017). Arch Pathol Lab Med. 141:144-50.

    [2] Wong ZW et al. (2015). World J Gastroenterol. 21(12):3694-705.

  • Advantage of QUARTETT Antibodies

    ADVANTAGES OF RECOMBINANT RABBIT MONOCLONAL ANTIBODIES

    Recombinant rabbit monoclonal antibodies—referred to as Q-clones—combine the best properties of both murine monoclonal and rabbit polyclonal antibodies, offering a broader diagnostic potential.

    Key Advantages of Our Next-Generation Recombinant Rabbit Monoclonal Antibodies

    ✔ High Affinity due to rabbit origin, enabling greater sensitivity in assays—these antibodies bind strongly to antigens and maintain their bond even under challenging conditions, unlike low-affinity antibodies.

    ✔ Superior Specificity with reduced risk of cross-reactivity, thanks to their monoclonal nature.

    ✔ Expanded Antigen Recognition—better recognition of diverse antigens and epitopes.

    ✔ Target Epitopes Poorly Recognized by Mouse-Derived Antibodies, improving detection in certain applications.

    ✔ Enhanced Response to Small-Sized Epitopes, making them ideal for challenging targets.

    ✔ Significantly Improved Recognition of Murine Antigens, broadening their usability in research and diagnostics.

    ✔ Lower Background Staining, ensuring cleaner and more reliable results.

    Recombinant vs. Hybridoma Antibody Generation

    ✔ Exceptional Consistency, Specificity, and Sensitivity—eliminating risks of gene loss, mutations, or cell line drift.

    ✔ Reliable and Controlled Production—generated from a unique gene set, ensuring stable antibody performance.

    ✔ Batch-to-Batch Consistency, guaranteeing reproducible results and long-term product availability.

    ✔ Efficient In Vitro High-Throughput Production, allowing easy standardization and scalable antibody expression for any application.

    Recombinant rabbit monoclonal antibodies represent the future of immunohistochemistry, offering unmatched reliability and precision in diagnostic and research settings.

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