Anti- Cadherin 17 (clone QR098)

Anti-Cadherin 17 (CDH17) – A Highly Sensitive Marker in Gastrointestinal Pathology
Cadherin 17 (CDH17), also known as liver-intestine cadherin or human peptide transporter-1 (HPT-1), belongs to the cadherin family. It is a calcium-dependent (Ca²⁺) adhesion molecule primarily expressed in intestinal epithelial cells. CDH17 plays a role in the morphological organization of the liver and intestines and is involved in peptide transport within the intestine.
CDH17 Expression in Tumors
Immunohistochemical staining for CDH17 is highly sensitive for detecting adenocarcinomas originating from:
✔ Colon
✔ Rectum
✔ Stomach
✔ Esophagus
Additionally, CDH17 expression, though less frequent, has been reported in:
✔ Pancreatic adenocarcinoma
✔ Mucinous ovarian carcinoma
✔ Neoplasms of the female reproductive tract
CDH17 as an Oncogene and Diagnostic Marker
Recent studies indicate that CDH17 expression is upregulated in gastric cancer, suggesting its role as an oncogene. It is implicated in:
✔ Cell proliferation
✔ Tumor growth
✔ Invasion and metastasis of gastric carcinoma
CDH17 demonstrates higher sensitivity for colorectal carcinoma compared to CK20 and CDX2, making it a valuable diagnostic tool.
Clinical Significance
✔ High CDH17 expression correlates with poor prognosis, increased cell proliferation, and enhanced metastatic potential in various malignancies.
✔ Its superior sensitivity in colorectal cancer supports its use as a key immunohistochemical marker in diagnostic pathology.